The Cayman Islands Government faced the unprecedented global COVID-19 pandemic by placing the health and safety of the population as the highest priority. This approach led to the closure of borders in March 2020 and ultimately the cessation of tourism, months of quarantine guided by Public Health and the implementation of strict regulations and safety measures throughout the nation. During this period, the Ministry and Department of Tourism worked continuously to respond to the needs of the industry by instituting measures to assist those who were suddenly faced with unemployment, closure of businesses, and coordinating efforts to ready the sector for the different phases of tourism’s return. The timeline presented here is a brief snapshot of those efforts.